• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    1. A METHOD FOR OBTAINING MEANS OF PROLONGED ACTION, including dispersion of the therapeutically active substance in a water-insoluble porous organic polymer, contains a therapeutically active substance, characterized in that, in order to evenly release the active substance, the aqueous phase is additionally prepared with a particle diameter of 1-5 microns a content of 2-30% of the total volume by dividing the required amount of water into several portions and introducing into them plasticizers, a wetting agent, buffer and hygroscopic substances, as well as a therapeutically active substance with subsequent dispersion of the obtained solutions separately in a polymer solution, after which the organic solvents and / or their mixture are evaporated, the therapeutically active substance and the mixture of tablets are applied to the resulting granulate, CO 2, the method according to claim 1, which differs by the fact that apovin-CAMINOH acid ethyl ester, butane sulfate, isosorbide dinitrate or reserpine are used as therapeutically active substances.
    公开号:SU1158030A3
    申请号:SU772524795
    申请日:1977-09-16
    公开日:1985-05-23
    发明作者:Добо Янош；Такач Ержебет；Хортобадьи Дьезе；Шкворец Марианне；Колбе Илона；Хоффманн Каталин
    申请人:Рихтер Гедеон Ведьесети Дьяр Рт (Инопредприятие)；
    IPC主号:
    专利说明:

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    About with Osgk t-: ATP / CoR polutoii filiO. ;;;) pcheg be Il-riuibix grapple {V.; T ps; in ohdg1: ieu akti i: v (-.: G; er:; :: HOTi; h;: Pvgg Siyusob receiving} 1G | ji.OjioHrnpoBaHHoro AeiicTBi i i: rf :: rfy; i; o; TnV r ispraggirovainu therapists Kj; i;; M-4 (s; i. Akg; nag substance in water v ;; iMf; -T or g aiiii i cKOM polymer e, n, -: T (rl: e ggiche ( , ki is active (; Od7 I (BH) - (and p. g 1G -reads - in a J i o m e 15 s with akgitgkich of substances; H: iij i: aH is available o., s (;; jQ eosobesu polutsni - ::; (jjiOHri jJOiaHirioro /.uststzi to; - ;; / gis; g: n-yoke} -ant e tera ;;; i:: - :: l ;; g;) yy1des1; chza in zo:}. ;; :::; .jм liIiecec .. ggoli-. V .с :: l. mountain. hygiene iO; -iiU-t, i; j (),; 1 (| Golnits; 11о N. T, 0 (L ;.Ч, l, -IJ-ierpOM. .Ix: - PM) h .-. I; -: - ;;; fvbeM paaju j,, cm (complementary; i h, : l: j LL / -LIS LL: lg: iTaf r, s: Achivagl, -1ak,::; lroslo111-g- es1; lh 2O: and (lll j l .ii;} rj-trr iKTinniOrO.: : -LS.chPPOiSHM L,) .. -, -: ;; -: -. L iu: -l or-z -ic -y:: l:;. ;;;; by; L measures:; .. los.:, L: lles; lga tlgs.1L31) p) ./rjcb -larivot, on the floor ;:. i; I: LHT. LZatteN GYa CHR: l ;; | , lg; zo -: l -:; - c tablet a; e t; k ll it ;;; p-; l aski aklvv sl .; lllllllllllllllllllllate OSH EF1 alKLlyuy kleslotk bametachsul, t slyusbilila lhch rel - r p 1,; OS g trill: e-L1ta; ; o: .j, p agglomerate in i.-00 ma digg, glgtl tanad-, To the obtained solution (L.L.L. 20 g. 1I: tshlengli.ko, cc docc, 3000), solution; nnotch} i; 80 m (mils, m; 3.: G. Pg: 1dny rastoror distributors LDA of Oi O S in a collective milling machine i-ek glr. Lokar particle diameter:.: OnBaKHC j phase is not equal ;;; alsr l, Sub- wl such as globally bm; lolp: -1sup anip in nfiTo.Ke asg -..yo G1); lhl11.HIjayuyu kachestve ve p; l: points, which spores an equal f1; with mol. m, 1 50-400, O p and W are about 1. l, according to the cell s.yamera p; L; a: hlpr ..-, a-vnll:, aa / ll that is compressed in ml of (xJO) ifIana, Sotsioshklir MOHo icpiiB 8: 2. By the way .aiopy add1. 20 MJ; ivnnreptnia p (the lashes will not be equal; -1 L;: .- ... .5 Received; Rastlop G-OS. DP and shrinkage in the stream of the Uttalu-g; g; pk Lrlen in a number of 1.; alupj-; a .ia d, l; h) si,}: o7O1) and sb ec1T (-l; l. aa;: lnnomerpos; B1, free ,,; ltl. .. pglvdgo BP: chos1L.; a with, mod.m ,; 00-600.; P jr M a p 3 100 g of termaetata pl; l: rasti) 0р гот в, consists of 1Л- 1080 ml l, ill. 1a and 1 20 - l of toluene, La.h. way to conduct-, kag in npib.iepp i. The resulting parr. L) p is vrigodod,. ;; sex luvol obol; l (to razlomermo vys) I wait; 1, -; x, a: L: ;;. (;, with LIHILCH, 300-600. P p and; with p l. 1000 g bAgStaksulpata s.S; I live with the PLN of the Yolochnaya salar .. Go to Oggsviyu loroshkoobravluk-sgss. La) i; okorno h.mochivyatg rast: ii lsd; aO go.shilppl-ltrroldoka in::.) vibrad1; oleohm device l (Apucha.l rpanyjTb of 2 gm in size, the cat l: g1e is vysuchivayut in the clear soup: 1Л1К-; or su ilka with lsevdozhikevnym with,: (oreg.: O1P5OI turn in the device grapul1; rovadn for getting hV; pasMeiiOr-i 0.8-1, 0 and then: from 20 g of stearate and 7) g (a, and vomovsv); oh mixture into ostral: ve / lt. pressing pressu tabletg weight-230 mgu and bottom MeTjjoii 9 mm, icoTopi / e tsiryut in a coating pan o5o: 10 with the help of a mat; In accordance with Example 1, application of a version of dd to obtain a rim cedesoobraboeno-carried out with a pneumatic or hydraulic gun. The rate of application of the liquid is 15-20 mm / min, air pressure / pressure in paciTbirnirenij 2,3-ii, .3 bar. The solvent is purified. warm air oil 30 temperatures (,
    权利要求:
    Claims (2)
    [1]
    1. METHOD FOR PRODUCING A LONG-TERM ACTION, including dispersing a therapeutically active substance in a water-insoluble organic polymer containing a therapeutically active substance, characterized in that, in order to uniformly isolate the active substance, an additional aqueous phase is prepared with a particle diameter of 1-5 μm with its content of 2 -30% of the total volume by dividing the required amount of water into several portions and introducing plasticizers, wetting agents, buffer and hygroscopic substances, as well as t therapeutically active substance with a blowing after dispersing the resulting solutions separately to the polymer solution, after which the organic solvents and / or their mixture is evaporated, the resulting granulate is applied to a therapeutically active agent and the mixture is tabletted.
    [2]
    2. The method according to claim 1, characterized in that as therapeutically active substances use ethyl ester of apovic acid, bametansulfate, isosorbide dinitrate or reserpine.
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    同族专利:
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    引用文献:
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    DK93751C|1959-02-18|1962-06-25|Abbott Lab|Method for coating tablets and liquid mixture for use in the method.|
    DK92805C|1959-02-18|1962-02-19|Abbott Lab|Method for coating tablets and similar solid drugs and liquid mixture for use in the method.|
    DK100254C|1961-06-13|1964-11-09|Abbott Lab|Coating agent for tablets.|
    US3148124A|1962-06-12|1964-09-08|William E Gaunt|Method of preparing sustained release pharmaceutical tablets|
    FR1534254A|1966-08-16|1968-07-26|Phytogen Products|Method for blocking and promoting estrus and blocking product|
    DE1617351A1|1967-06-28|1972-01-05|
    SE324859B|1967-09-04|1970-06-15|Ercopharm As|
    US3655129A|1968-07-17|1972-04-11|Ppg Industries Inc|Slow release films and methods of making same|
    GB1276089A|1968-08-23|1972-06-01|Pfizer Ltd|Pharmaceutical preparations|
    US3773919A|1969-10-23|1973-11-20|Du Pont|Polylactide-drug mixtures|
    BE791632A|1971-11-20|1973-05-21|Schering Ag|SILICONIC RUBBER-BASED SUPPORTS FOR MEDICINAL PRODUCTS|
    GB1425550A|1973-04-25|1976-02-18|Alza Corp|Device for releasing active agent and process for producing the same|
    US3923939A|1974-06-07|1975-12-02|Alza Corp|Process for improving release kinetics of a monolithic drug delivery device|
    US3946106A|1974-10-24|1976-03-23|G. D. Searle & Co.|Microsealed pharmaceutical delivery device|DE2966893D1|1978-10-02|1984-05-17|Purdue Research Foundation|Foods and pharmaceutical coating composition, method of preparation and products so coated|
    CH647676A5|1978-12-22|1985-02-15|Donald E Panoz|ORAL, PROGRAM RELEASED GALENIC FORMS AND METHODS OF PREPARING THE SAME.|
    FR2470599B1|1979-12-07|1983-03-25|Panoz Donald|
    JPS5911563B2|1980-02-27|1984-03-16|Japan Atomic Energy Res Inst|
    JPS6337081B2|1982-03-12|1988-07-22|Kuraray Co|
    EP0211991B1|1982-07-08|1989-10-25|Ab Leo|Substained release tablets and method for preparation thereof|
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    JPS59190925A|1983-04-12|1984-10-29|Shin Etsu Chem Co Ltd|Enteric coating composition|
    US4548990A|1983-08-15|1985-10-22|Ciba-Geigy Corporation|Crosslinked, porous polymers for controlled drug delivery|
    US4587069A|1983-10-31|1986-05-06|Twinoak Products, Inc.|Process for producing color display means|
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    法律状态:
    优先权:
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    HU76RI596A|HU174057B|1976-09-17|1976-09-17|Coating material for the regulated release of the active substance in biologically active preparations and process for preparing such preparations with regulated release of the active substance|
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